ABSTRACT
Hepatoprotective and antioxidant properties of Suaeda maritima (L.) Dumort on concanavalin-A induced stress in Wistar albino rats have been reported. Rats were administered with ethanolic extract of Suaeda maritima at the concentration of 75, 150 and 300 mg/kg of body wt. for 9 days and concanavalin-A was administrated (iv) 12 mg/kg on 9th day. Rats in concanavalin-A administered group showed elevated levels of AST, ALT, ALP and bilurubin. Pretreatment of rats with ethanolic extract (300 mg/kg) significantly reduced these serum parameters compared to concavalin-A administered group. Histopathological examination of liver sections showed that, normal liver architecture was disturbed by hepatotoxin intoxication. The extract treated group and silymarin treated group retained the normal cell architecture, although less visible changes were observed. Preliminary phytochemical analysis showed the presence of triterpenioids and may be responsible for the hepatoprotective activity. The LD50 was calculated as 3 g/kg of the body weight. IC50 values of hydroxyl (52.21±1.32g/ml) and nitric oxide radicals (09.14±0.94 g/ml) scavenging results showed comparable activity with vitamin-C. Results of this study may be useful for the development of herbal medicine from Suaeda maritima for the treatment of hepatitis.
ABSTRACT
Study of marine organisms for their bioactive potential, being an important part of marine ecosystem, has picked up the rhythm in recent years with the growing recognition of their importance in human life. Investigation was carried out to isolate 32 strains of endo and epiphytic bacteria in 2 seagrass species viz., Syringodium isoetifolium and Cymodocea serrulata. Morphologically different bacterial strains were tested against 5 antibiotic resistant human bacterial pathogens, of which 10 associated bacteria shown inhibitory activity against one or more bacterial pathogens. Minimum inhibitory concentration (MIC) and Minimum bacterial concentration (MBC) determination with extracellular bioactive compounds from the associated bacteria reveals that, the strain ENC 5 showed inhibitory activity against all the bacterial pathogens with the maximum sensitivity against Pseudomonas aeruginosa at the MIC value of 500 µg ml-1.
ABSTRACT
The chosen phosphobacterial species are well tolerated to the wide range of salinity (20-40 ppt) and found to be pure marine forms. Effect of different concentrations of cadmium on the growth, phosphate solubilising activity and content of extracellular macromolecules in eight species of phosphate solubilising bacteria were carried-out in the present study at optimum level of salinity and found that these activities are found maximum at lower concentrations of cadmium and further reduction in the activities were noticed at higher concentrations. The maximum content of total sugar was noticed in S. aureus at 1 ppm level of cadmium. The content of protein was found maximum in B. megaterium and M. roseus without the addition of cadmium and also the phosphate solubilizing activity was found higher in all the chosen phosphobacterial strains with the addition of cadmium.